Social Stress Increases Anxiety by GluA1-Dependent Synaptic Strengthening of Ventral Tegmental Area Inputs to the Basolateral Amygdala
Potentiation of VTA inputs increased synaptic integration, thereby enhancing amygdala activity and promoting maladaptive anxiety. Understanding the impact of amygdala hyperactivity may lead to targeted therapies that restore circuit balance and offer new precision medicine approaches for anxiety disorders.
Authors
- Christelle Glangetas (ORCID: https://orcid.org/0000-0001-9544-4277)
- Sebastián P. Fernández (ORCID: https://orcid.org/0000-0003-0683-5562)
- Jacques Barik (ORCID: https://orcid.org/0000-0002-4276-0927)
- Thomas Contesse (ORCID: https://orcid.org/0000-0001-8873-3871)
- M. Flavia Barbano (ORCID: https://orcid.org/0000-0001-5477-3592)
- Hugo Fofo (ORCID: https://orcid.org/0000-0001-8794-0828)
- Mariano Soiza‐Reilly (ORCID: https://orcid.org/0000-0002-5800-865X)
- Léa Royon (ORCID: https://orcid.org/0000-0002-5598-1948)
- Joana Gomes-Ribeiro
- Anaëlle Braine
- Shiliang Zhang (ORCID: https://orcid.org/0009-0006-5010-1151)
- François Georges (ORCID: https://orcid.org/0000-0002-7869-1919)
Institutions
- Centre National de la Recherche Scientifique (FR)
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- Institut des Maladies Neurodégénératives (FR)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.biopsych.2025.04.007
- Citations
- 4
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 4.45
Funders
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Fédération pour la Recherche sur le Cerveau
- Institut pour la Recherche en Santé Publique
- National Institutes of Health
- National Institute on Drug Abuse
- National Cancer Institute