Exploring the impact of Gastrodin on brain aging in mice: Unraveling mechanisms through network pharmacology
GAS demonstrates a pronounced alleviating effect on age-related symptoms in D-galactose-induced brain aging mice by suppressing oxidative stress in the mouse brain. The mechanism involves the upregulation of cellular autophagy through the AMPK/mTOR/ULK1 signaling pathway.
Authors
- Jinghui Miao (ORCID: https://orcid.org/0000-0001-6371-0606)
- Ying Wang (ORCID: https://orcid.org/0000-0002-5223-4074)
- Jinpeng Li (ORCID: https://orcid.org/0009-0007-2572-117X)
- Sha Zheng (ORCID: https://orcid.org/0000-0003-2791-5107)
- Rui Yuan (ORCID: https://orcid.org/0009-0003-7441-7829)
Institutions
- Dali University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bbrc.2025.151814
- Citations
- 1
- Primary Topic
- Biological and pharmacological studies of plants
- Type
- article
- Field-Weighted Citation Impact
- 1.39