Global Trends in CD4 Measurement and Immunosuppression at ART Initiation Among Children With HIV
Eligibility for antiretroviral therapy is no longer based on immune criteria. In a global cohort of 97,453 children, between 2005 and 2021, we observed large declines in CD4 measurement, from 51% to 12% among <5 seconds, and from 74% to 20% among those 5-14 years of age. Lack of CD4 testing may negatively affect clinical care and surveillance of severe immune suppression.
Authors
- Aarti Kinikar (ORCID: https://orcid.org/0000-0001-9466-1130)
- Nathan Ford (ORCID: https://orcid.org/0000-0001-8238-4228)
- Karen Malateste
- Kara Wools‐Kaloustian (ORCID: https://orcid.org/0000-0002-3277-4452)
- Sophie Desmonde (ORCID: https://orcid.org/0000-0001-9372-2819)
- Madeleine Amorissani‐Folquet (ORCID: https://orcid.org/0000-0001-6101-5810)
- Vanessa Rouzier (ORCID: https://orcid.org/0000-0002-9672-9474)
- Jorge Pinto (ORCID: https://orcid.org/0000-0001-6344-8636)
- Francesca Odhiambo (ORCID: https://orcid.org/0000-0002-3503-2294)
- Valériane Leroy (ORCID: https://orcid.org/0000-0003-3542-8616)
- Carolyn Bolton‐Moore (ORCID: https://orcid.org/0000-0001-9103-7746)
- Marcel Yotebieng (ORCID: https://orcid.org/0000-0003-2110-2631)
- Charles Kasozi
- Peter Vanes Ebasone
- Nel Jason Haw (ORCID: https://orcid.org/0000-0003-2602-4214)
- Gabriela Patten (ORCID: https://orcid.org/0000-0003-2511-1367)
- Daisy Maria Machado (ORCID: https://orcid.org/0000-0003-1993-6442)
- Nosisa Sipambo (ORCID: https://orcid.org/0000-0003-0058-6884)
- Nanina Anderegg
- Revathy Nallusamy
- Dư Tuấn Quy
- Denna Michael
- Dewi Kumara Wati
- Patricia Lelo
- Limpho Mokone
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Bern (CH)
- Udayana University (ID)
- Centre for Infectious Disease Research in Zambia (ZM)
- Albert Einstein College of Medicine (US)
- Université Toulouse III - Paul Sabatier (FR)
- Johns Hopkins University (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Cape Town (ZA)
- B. J. Medical College & Sassoon Hospital (IN)
- Chris Hani Baragwanath Hospital (ZA)
- Masaka Hospital (UG)
- Kinshasa General Hospital (CD)
- Penang Adventist Hospital (MY)
- Kenya Medical Research Institute (KE)
- World Health Organization (CH)
- Bordeaux Population Health (FR)
- Geriatric Research Education and Clinical Center (US)
- Institute of Social and Preventive Medicine (CH)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Gheskio Centers (HT)
- Children's Hospital 1 (VN)
- Centre Hospitalier Universitaire de Cocody (CI)
- National Institute for Medical Research (TZ)
- Institut de Recherche pour le Développement (FR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1097/inf.0000000000004819
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00