Safety and quality of life of PSMA-PET- and MRI-based focal dose escalated radiotherapy for intermediate- and high-risk prostate cancer: Primary endpoint analysis of the bi-centric phase II HypoFocal trial (ARO2020-01)
This is the first trial do demonstrate safety and feasibility of focal dose-escalation based on mpMRI and PSMA-PET in MHRT and HDR-BT + EBRT in intermediate- and high-risk PCa. Particularly, HDR-BT offers good toxicity and QoL profiles. Radiation proctitis demands careful management.
Authors
- Sebastian Zschaeck (ORCID: https://orcid.org/0000-0003-3109-0662)
- Christian Gratzke (ORCID: https://orcid.org/0000-0003-4070-0952)
- Michael Mix (ORCID: https://orcid.org/0000-0002-9106-2519)
- August Sigle (ORCID: https://orcid.org/0000-0001-6857-8149)
- Simon Kirste (ORCID: https://orcid.org/0000-0001-5556-6069)
- Simon K. B. Spohn (ORCID: https://orcid.org/0000-0003-2727-8005)
- Mark Gainey (ORCID: https://orcid.org/0000-0002-0074-3328)
- Pirus Ghadjar (ORCID: https://orcid.org/0000-0002-2747-165X)
- Fabian Bamberg (ORCID: https://orcid.org/0000-0002-7460-3942)
- P. Toncheva
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- Sophia L. Bürkle
- Marius Kamps
- Joachim Brumberg (ORCID: https://orcid.org/0000-0003-0959-4776)
- Sonja Adebahr
- Cordula A. Jilg (ORCID: https://orcid.org/0000-0001-5823-5679)
- Martin T. Freitag (ORCID: https://orcid.org/0000-0002-2116-6873)
- Tanja Sprave (ORCID: https://orcid.org/0000-0003-1292-1352)
- Constantinos Zamboglou (ORCID: https://orcid.org/0000-0002-7849-7550)
- Hannes Engel (ORCID: https://orcid.org/0000-0003-1985-325X)
- Dimos Baltas (ORCID: https://orcid.org/0000-0003-4220-9083)
Institutions
- University Medical Center Freiburg (DE)
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.radonc.2025.110883
- Citations
- 7
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.63