Brain morphometry and psychomotor development in children with PCH2A
MRI in PCH2A patients shows limited cerebellar growth during infancy, especially restricted along the cranio-caudal axis. After infancy, cerebellar volume remains relatively stable. Supratentorial measurements indicate slowly progressive atrophy. Psychomotor development is significantly impaired, but regression is rare.
Authors
- Elias Kellner (ORCID: https://orcid.org/0000-0001-9494-2354)
- Simone Mayer (ORCID: https://orcid.org/0000-0002-6381-2474)
- Wibke G. Janzarik (ORCID: https://orcid.org/0000-0002-3651-1385)
- Lucia Laugwitz (ORCID: https://orcid.org/0000-0003-2506-1961)
- Markus Uhl (ORCID: https://orcid.org/0000-0002-5128-0861)
- Maren Hackenberg (ORCID: https://orcid.org/0000-0003-4403-634X)
- Pablo Pretzel (ORCID: https://orcid.org/0000-0001-5834-5587)
- Samuel Groeschel (ORCID: https://orcid.org/0000-0002-2706-7163)
- Anna‐Lena Klauser
- Julia Matilainen
- Antonia Herrmann
- Alice Kuhn
Institutions
- Karlsruhe Institute of Technology (DE)
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- TUM Klinikum (DE)
- Deutsche Telekom (Germany) (DE)
- Zimmer Biomet (Germany) (DE)
- University Children's Hospital Tübingen (DE)
- Hertie Institute for Clinical Brain Research (DE)
Publication Details
- Journal
- European Journal of Paediatric Neurology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.ejpn.2025.04.004
- Citations
- 1
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Silicon Valley Community Foundation
- Chan Zuckerberg Initiative
- Deutsche Forschungsgemeinschaft
- Albert-Ludwigs-Universität Freiburg