Follicular fluid concentrations of the vitamin D metabolite 24,25(OH)2D3 are positively associated with live birth rate after assisted reproductive technology
This study reveals that high levels of 24,25(OH)<sub>2</sub>D<sub>3</sub> and low levels of the 1,25(OH)<sub>2</sub>D<sub>3</sub>/24,25(OH)<sub>2</sub>D<sub>3</sub> ratio in follicular fluid are associated with increased live birth rates in women undergoing IVF/ICSI treatment. Conversion of vitamin D metabolites systemically or in the ovarian follicle may affect ART outcome. Further studies are warranted to support the findings from this pilot study and identify regulators of ovarian vitamin D metabolites.
Authors
- Martin Blomberg Jensen (ORCID: https://orcid.org/0000-0003-3800-4253)
- Anders Hayden Berg (ORCID: https://orcid.org/0000-0002-5736-0686)
- Anne Jørgensen (ORCID: https://orcid.org/0000-0002-6409-198X)
- Anders Juul (ORCID: https://orcid.org/0000-0002-0534-4350)
- Stine Gry Kristensen (ORCID: https://orcid.org/0000-0003-1194-8393)
- Li Juel Mortensen (ORCID: https://orcid.org/0000-0002-8995-9116)
- Ireen Kooij
- Hans Krog
- Mette Lorenzen (ORCID: https://orcid.org/0000-0001-5586-7515)
- Rune Holt (ORCID: https://orcid.org/0000-0002-2489-3216)
- Ursula Bentin-Ley
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Dansk Fertilitetsklinik (DK)
Publication Details
- Journal
- The Journal of Steroid Biochemistry and Molecular Biology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jsbmb.2025.106764
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Novo Nordisk Fonden