Ligand-Controlled Preparation of Aryl-Substituted Allenes Enabled by Nickel-Catalyzed Reductive Coupling of Secondary Propargylic Carbonates with Aryl Halides

Herein, we developed a new method for the synthesis of aryl-substituted allenes through a nickel-catalyzed reductive coupling reaction between secondary propargyl carbonates and aryl halides. By employing the dimethyl-1,10-phenanthroline ligand, we achieved a ligand-controlled, regioselective nickel-catalyzed reductive arylation, overcoming the structural limitations of propargyl electrophiles. Notably, this reaction exhibits exceptional functional group compatibility, rendering it particularly suitable for late-stage allenylation modifications of complex molecules.