A new seco-iridoid glycoside from fruits of <i>Cornus officinalis</i> Sieb. et Zucc and their neuroprotective activities

A new seco-iridoid glycoside, named neocornuside I (<b>1</b>), together with seven previously reported compounds (<b>2</b>-<b>8</b>) were isolated from fruits of <i>Cornus officinalis</i> Sieb. et Zucc. Their structures were determined by extensive analysis of HRESIMS, IR, UV, 1D and 2D NMR spectral data. The isolated compounds (<b>1</b>-<b>8</b>) were evaluated for their <i>in vitro</i> neuroprotective activities. Based on flow cytometry results, compound <b>1</b> was found to alleviate apoptosis and G2/M phase arrest, indicating its considerable neuroprotective effects.