Effects of weight loss and weight gain on HbA<sub>1c</sub>, systolic blood pressure and total cholesterol in three subgroups defined by blood glucose: a pooled analysis of two behavioural weight management trials in England
Cardiometabolic risk factors are associated with changes in weight. The association with HbA<sub>1c</sub> varies by diabetes status, with increasing magnitude in those with non-diabetic hyperglycaemia and T2D. Weight gain has a larger impact on HbA<sub>1c</sub> than weight loss in individuals with normoglycaemia, implying an asymmetric relationship.
Authors
- Amy L. Ahern (ORCID: https://orcid.org/0000-0001-5069-4758)
- Simon J. Griffin (ORCID: https://orcid.org/0000-0002-2157-4797)
- Alan Brennan (ORCID: https://orcid.org/0000-0002-1025-312X)
- Katharine Pidd (ORCID: https://orcid.org/0009-0007-7112-4763)
- Penny R. Breeze (ORCID: https://orcid.org/0000-0002-4189-8676)
Institutions
- University of Cambridge (GB)
- MRC Epidemiology Unit (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-095046
- Citations
- 5
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Institute for Health and Care Research
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre