Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients

CA causes typical histopathological HIE patterns, with the hippocampus being more susceptible to SEND, than the cerebral neocortex, and the brainstem being the most resistant brain region. The neocortical distribution of SEND is mostly homogeneous; however, a relevant subgroup shows substantial neocortical HIE heterogeneity. Further studies are required to provide a more granular histopathological analysis of infrequent HIE patterns and their implications for neuroprognostication.