IGF-1 signaling pathway activation promotes axonal regeneration and repair: A mechanism study on catalpol-induced functional recovery after ischemic stroke
Our research elucidates that catalpol improves neurological recovery in ischemic stroke by regulating the IGF-1 signaling pathway to promote axonal regenerative repair, providing a new perspective for addressing the challenge of functional recovery in ischemic stroke.
Authors
- Hua Hao (ORCID: https://orcid.org/0000-0001-9292-2675)
- Dan Wu (ORCID: https://orcid.org/0000-0001-8041-4016)
- Minghua Wu (ORCID: https://orcid.org/0000-0002-6701-8825)
- Shirley H. J. Mei (ORCID: https://orcid.org/0000-0003-4727-1177)
- Yan Liu (ORCID: https://orcid.org/0000-0003-2918-5398)
- Li Li (ORCID: https://orcid.org/0000-0001-6131-4394)
- Jianguo G. Zhu (ORCID: https://orcid.org/0000-0002-9763-4047)
- Wenlei Li (ORCID: https://orcid.org/0000-0003-3960-6512)
- Xiaohui Yan
- Xinyu Xu (ORCID: https://orcid.org/0000-0002-5040-0171)
- Yang Wu (ORCID: https://orcid.org/0009-0008-9131-9995)
Institutions
- Jiangnan University (CN)
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jep.2025.119808
- Citations
- 5
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.03