Clinicopathologic Analysis of Dermatofibroma: A Retrospective Study of 165 Cases

Dermatofibroma (DF), also known as benign fibrous histiocytoma, is a common benign skin tumor whose clinicopathologic features and pathogenesis remain only partially understood. In this retrospective study, 165 cases of DF diagnosed between 2018 and 2024 were analyzed to characterize demographic, clinical, and histopathologic profiles. Data regarding patient age, gender, horizontal tumor size, anatomical location, and pathological subtypes were extracted from digital pathology archives. Statistical analyses revealed that male patients exhibited significantly larger horizontal tumor sizes compared to female patients (P = 0.027). Additionally, the tumor location was significantly associated with size, with lesions in the subcutaneous tissue showing larger mean horizontal dimensions than those in the reticular or papillary dermis (P = 0.032). These findings suggest that gender, tumor location, and pathological subtype are influential factors in DF growth, providing further insight into its clinical behavior and potential underlying mechanisms. These findings highlight the importance of considering patient gender and tumor location in the clinical management of DF, potentially guiding personalized treatment strategies and improving patient outcomes.