LINC02167 stabilizes KSR1 mRNA in an m5C-dependent manner to regulate the ERK/MAPK signaling pathway and promotes colorectal cancer metastasis
This study uncovers a novel mechanism through which LINC02167 promotes the ERK/MAPK pathway and CRC metastasis via m<sup>5</sup>C modification, underscoring its potential as a promising therapeutic target for metastatic CRC treatment.
Authors
- Ning Ma
- Tao Jiang (ORCID: https://orcid.org/0000-0002-5848-1922)
- Junwen Qi (ORCID: https://orcid.org/0000-0001-6587-5797)
- Song Hu (ORCID: https://orcid.org/0000-0003-0173-7162)
- Junnan Chen
- Bowen Liu (ORCID: https://orcid.org/0000-0001-8837-7870)
- Yixin Xu (ORCID: https://orcid.org/0000-0003-2164-1483)
- Qihang Hu
- Jun Song (ORCID: https://orcid.org/0000-0002-6350-2695)
Institutions
- Xuzhou Medical College (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s13046-025-03368-w
- Citations
- 6
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province