Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy
Overall, we suggested that the overexpression or activation of PPARα can inhibit FAO energy dysfunction of corneal endothelium and the abnormal extracellular matrix formation in Descemet's membrane, which is the primary pathology of FECD. Thus, PPARα may be a potential target for attenuating the progression of FECD.
Authors
- Mingxiong Chen (ORCID: https://orcid.org/0000-0002-3239-8135)
- Tunan Sun
- Haolan Qi (ORCID: https://orcid.org/0000-0002-3930-1228)
- Yannan Zhou (ORCID: https://orcid.org/0000-0002-5371-9591)
- Liqiang Wang (ORCID: https://orcid.org/0000-0002-6066-076X)
- Jie Wu (ORCID: https://orcid.org/0000-0002-3004-0025)
- Xiaoqi Li (ORCID: https://orcid.org/0000-0001-7200-2134)
- Junyi Wang (ORCID: https://orcid.org/0000-0003-0464-4543)
- Anqi Liu (ORCID: https://orcid.org/0000-0002-0468-5698)
- Yifei Huang
Institutions
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- People's Liberation Army 401 Hospital (CN)
- State Key Laboratory of Kidney Diseases
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1167/iovs.66.4.36
- Citations
- 2
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.72