Light-Induced Electrode Scanning Microscopy
Patch clamps and microelectrode arrays have been widely used to detect the electrical properties of cells in biomedicine. Yet, both technologies can record signals only in an invasive manner or at fixed positions. Based on the resolution (LAPS) and optically induced dielectrophoretic, we present a novel light-induced electrode scanning microscopy. It works like a "radar", scans the whole area with living cells in culture, and detects the electrical signals of single cells on a photosensitive chip. In the system, a light pattern projected onto the chip is used to form the corresponding light-induced electrode, and the electrode scanning mode is implemented by moving the light pattern or the chip position for the measurement of the electrical characteristics of biological cells and cell localizations. It provides a new tool for the detection of cell electrical properties and is expected to become the next generation of electrophysiological detection technology.
Authors
- Huanzhou Yang (ORCID: https://orcid.org/0000-0002-6466-184X)
- M. James C. Crabbe
- Mingdong Dong (ORCID: https://orcid.org/0000-0002-2025-2171)
- Jianjun Dong (ORCID: https://orcid.org/0000-0002-4085-4073)
- Fengyan Hou
- Zuobin Wang (ORCID: https://orcid.org/0000-0002-7168-0918)
- Tianzhu Yu
- Xia Wang (ORCID: https://orcid.org/0000-0003-4645-9768)
- Rui Wang (ORCID: https://orcid.org/0009-0009-3413-940X)
- Qiuyang Deng
Institutions
- Changchun University of Science and Technology (CN)
- University of Bedfordshire (GB)
- Aarhus University (DK)
- Center for NanoScience (DE)
- University of Oxford (GB)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1021/acs.analchem.4c05588
- Citations
- 1
- Primary Topic
- Electrochemical Analysis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- National Natural Science Foundation of China
- China Scholarship Council
- Higher Education Discipline Innovation Project
- Zhongshan Science and Technology Bureau
- HORIZON EUROPE Framework Programme
- National Key Research and Development Program of China
- Jilin Scientific and Technological Development Program