Generation and Characterization of a Human-Derived iPSC line from a female child with First-Episode of sporadic schizophrenia
Schizophrenia is a highly heritable neurodevelopmental disorder. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from a female child diagnosed with first-episode of sporadic schizophrenia. Induced pluripotent stem cells (iPSCs) were generated by introducing the reprogramming factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. The iPSC line was confirmed through karyotyping and the expression of key pluripotency markers. These cells demonstrated the ability to differentiate into all three germ layers in vivo.
Authors
- Peiyan Ni (ORCID: https://orcid.org/0000-0003-4889-7032)
- Xinyi Ren
- Chuqing Zhou (ORCID: https://orcid.org/0000-0002-0125-0365)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-6321-2137)
- Youhui Jiang
- Tao Li (ORCID: https://orcid.org/0000-0003-3831-901X)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-1715-8758)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Zhejiang Lab (CN)
- Hangzhou Seventh Peoples Hospital (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.scr.2025.103713
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82