Elevated serum concentrations of GFAP in hereditary transthyretin amyloidosis since pre-symptomatic stages
sGFAP and sNfL mark distinct ATTRv stages, with sGFAP indicating early preclinical changes and sNfL correlating with neurological progression. Sex differences in sGFAP levels among HCs suggest that sex should be considered as a covariate in biomarker analyses.
Authors
- Maurizio Inghilleri (ORCID: https://orcid.org/0000-0001-5365-3417)
- Stefano Tozza (ORCID: https://orcid.org/0000-0002-9672-4577)
- Angela Stufano (ORCID: https://orcid.org/0000-0002-9101-7742)
- Domenico Plantone (ORCID: https://orcid.org/0000-0001-6666-7244)
- Francesca Vitali (ORCID: https://orcid.org/0000-0002-3177-1575)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-4930-7639)
- Marco Luigetti (ORCID: https://orcid.org/0000-0001-7539-505X)
- Valeria Guglielmino (ORCID: https://orcid.org/0000-0002-9049-5988)
- Carlo Manco (ORCID: https://orcid.org/0000-0003-4572-2616)
- Ângela Romano (ORCID: https://orcid.org/0000-0002-2061-1509)
- Guido Primiano (ORCID: https://orcid.org/0000-0001-7616-7008)
- Andrea Sabino (ORCID: https://orcid.org/0009-0007-5257-374X)
- Maria Laura Stromillo
- Fiore Manganelli (ORCID: https://orcid.org/0000-0002-1442-9604)
- Luca Leonardi (ORCID: https://orcid.org/0000-0002-1267-864X)
- Francesca Forcina (ORCID: https://orcid.org/0009-0002-2572-5801)
- Delia Righi (ORCID: https://orcid.org/0009-0001-3352-5618)
- Marco Ceccanti (ORCID: https://orcid.org/0000-0001-8897-3736)
- Paolo Calabresi (ORCID: https://orcid.org/0000-0003-0326-5509)
- Maria Ausilia Sciarrone (ORCID: https://orcid.org/0000-0002-1490-0320)
Institutions
- University of Siena (IT)
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Neurologico Mediterraneo (IT)
- CTO Andrea Alesini (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1007/s00415-025-13072-6
- Citations
- 2
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Pfizer
- Università degli Studi di Siena
- Ministero della Salute