Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress
Our study investigated the heterogeneous response of the scallop heart to high temperatures, revealing distinct response patterns between VMs and AMs. We further identified a key gene, AiPLRP2-like, which exhibits unique cellular localization patterns compared to its mammalian counterpart and may play a pivotal role in regulating cardiac thermotolerance in organisms with open circulatory systems. These findings provide novel insights into the theoretical framework and evolutionary adaptations of marine invertebrate hearts in response to environmental temperature fluctuations.
Authors
- Xinghai Zhu
- Na Liu (ORCID: https://orcid.org/0009-0002-0017-2307)
- Danyang Wang (ORCID: https://orcid.org/0000-0003-3678-0996)
- Jingjie Hu (ORCID: https://orcid.org/0000-0002-0715-7137)
- Zhenmin Bao (ORCID: https://orcid.org/0000-0001-6126-0509)
- Yangfan Wang (ORCID: https://orcid.org/0000-0002-7000-4213)
- Xiangfu Kong (ORCID: https://orcid.org/0000-0003-4658-8615)
Institutions
- Ocean University of China (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12915-025-02210-1
- Citations
- 1
- Primary Topic
- Physiological and biochemical adaptations
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Postdoctoral Innovation Project of Shandong Province