Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study
Elevated plasma <i>L</i>-aspartic acid levels significantly increased the risk of developing GC and modified the effects of GC primary prevention. Further studies from other populations are warranted to validate the modification effect of plasma <i>L</i>-aspartic acid levels on GC prevention and to elucidate the underlying mechanisms.
Authors
- Wei‐Cheng You (ORCID: https://orcid.org/0000-0003-2190-1812)
- Hengmin Xu
- Zhou Tong (ORCID: https://orcid.org/0000-0002-9867-2838)
- Zongchao Liu (ORCID: https://orcid.org/0000-0002-2008-3793)
- Kai‐Feng Pan (ORCID: https://orcid.org/0000-0002-3680-3126)
- Wenqing Li (ORCID: https://orcid.org/0000-0002-8336-5552)
- Mengyuan Wang (ORCID: https://orcid.org/0000-0003-2077-361X)
- Sha Huang (ORCID: https://orcid.org/0000-0001-9107-1354)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-4533-4325)
- Wenhui Wu (ORCID: https://orcid.org/0009-0008-8773-2832)
- Zhouyi Yin
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2024.0523
- Primary Topic
- Garlic and Onion Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Peking University
- National Science and Technology Major Project