A Two‐Photon Excited Organic Laser Material for Nano‐Theranostics
Abstract Integrated diagnosis and treatment, i.e. theragnosis, has become a crucial concept in the future of the healthcare field. In this work, the properties of organic lasers are utilized for the design of nano‐theranostic probes. By ingeniously modifying the distyrylbenzene structure, it achieves high two‐photon absorption cross‐sections and maintains low‐threshold laser performance, achieving two‐photon excitation (2PE) organic nano‐rod lasers. These nano‐rods exhibit 2PE laser properties and high singlet oxygen production efficiency, marking their emergence as integrated nano‐theranostic agents. The novel nano‐theranostic agents demonstrate the application of 2PE laser for in vivo imaging and 2PE photodynamic therapy treatment of melanoma, showcasing their potential to perform simultaneous tumor staging and therapy. The success of the organic 2PE laser reagent in melanoma models underscores its potential for early detection, enhanced imaging, and effective treatment, offering a promising new direction for integrated cancer theranostics.
Authors
- Ruilin Yang (ORCID: https://orcid.org/0000-0003-4476-0717)
- Zitong Liu (ORCID: https://orcid.org/0000-0003-1185-9219)
- Jiannian Yao (ORCID: https://orcid.org/0000-0001-5505-1911)
- Chun‐Lin Sun (ORCID: https://orcid.org/0000-0001-8936-6129)
- Hongbing Fu (ORCID: https://orcid.org/0000-0003-4528-189X)
- Hao‐Li Zhang (ORCID: https://orcid.org/0000-0002-6322-5202)
- Jun Li (ORCID: https://orcid.org/0000-0002-5778-1616)
- Juan Ye (ORCID: https://orcid.org/0000-0002-2838-6836)
- Fukang Yuan (ORCID: https://orcid.org/0000-0001-8495-3818)
Institutions
- Northwestern Polytechnical University (CN)
- Xuzhou Medical College (CN)
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Xuzhou Central Hospital (CN)
- State Key Laboratory of Applied Organic Chemistry
- State Key Laboratory for Structural Chemistry of Unstable and Stable Species
- Lanzhou University (CN)
- Capital Normal University (CN)
Publication Details
- Journal
- Laser & Photonics Review
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1002/lpor.202500299
- Citations
- 4
- Primary Topic
- Nonlinear Optical Materials Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- Lanzhou University
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Natural Science Basic Research Program of Shaanxi Province