Inhibits Diabetes from Plectranthus amboinicus (Lour.)

Objective: To investigate the chemical composition of Plectranthus amboinicus (Lour.) collected from Dak Lak Province using combined chromatography, which has isolated two compounds. Subject and Research Methods: Investigation of the chemical composition of Plectranthus amboinicus (Lour.) collected from Dak Lak Province. Research Methods: Combined use of modern spectroscopic methods (Mass Spectrometry (EI-MS), Nuclear Magnetic Resonance (1H-NMR, 13C-NMR)). Results and Discussion: The chemical composition of Plectranthus amboinicus (Lour.) collected from Dak Lak Province was investigated. Using combined chromatography, two compounds were isolated. Modern spectroscopic methods (Mass Spectrometry (EI-MS), Nuclear Magnetic Resonance (1H-NMR, 13C-NMR)) were used to determine the structures of the two compounds, which were identified as β-sitosterol and Stigmasterol. These two compounds are commonly found in various plant species and have also been isolated for the first time in studies on Plectranthus amboinicus. Compound 1 exhibited the ability to inhibit α-amylase and α-glucosidase enzymes with IC50 values of 1375.50±92.45 and 966.31±80.01 μg/ml, respectively; compound 2 showed inhibitory activity on α-amylase and α-glucosidase enzymes with IC50 values of 1205.93±100.24 and 1025,24±67,52 μg/ml, respectively.