Total flavonoids of litchi seed inhibit breast cancer metastasis by regulating the PI3K/AKT/mTOR and MAPKs signaling pathways
TFLS effectively inhibits breast cancer cell proliferation, migration, and invasion <i>in vitro</i> by reversing the EMT phenotype, while suppressing metastasis <i>in vivo</i>. These effects are likely mediated <i>via</i> the attenuation of the PI3K/AKT/mTOR and MAPK signaling pathways.
Authors
- Dianxin Cui (ORCID: https://orcid.org/0000-0003-0566-3500)
- Xin Ming Yang (ORCID: https://orcid.org/0000-0003-1284-2515)
- Zhiheng Su (ORCID: https://orcid.org/0000-0002-3908-3208)
- Shoushi Liu
- Yuanshuo Wang
- Hongwei Guo (ORCID: https://orcid.org/0000-0002-4046-2643)
- Taijin Lan (ORCID: https://orcid.org/0000-0002-3038-5373)
- Ying Liu (ORCID: https://orcid.org/0000-0002-6540-0473)
- Dan Zhu (ORCID: https://orcid.org/0000-0003-3917-7738)
- Erwei Hao (ORCID: https://orcid.org/0000-0001-7394-6022)
- Lilan Qin
Institutions
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1080/13880209.2025.2488135
- Citations
- 6
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 4.65
Funders
- National Natural Science Foundation of China