Aryne Alder-Ene Reaction Enables Arylation of Conformationally Locked Styrenes
We report a transition metal-free aryne Alder-ene (AAE) reaction of conformationally locked styrenes like methylene indane (5,6-fusion) and methylene tetralin (6,6-fusion) to provide aryl-decorated indenes and dihydronaphthalenes. DFT studies compared the transition states between 5,6- and 6,6-fused systems. The synthetic utility of the 5,6- and 6,6-fused products was demonstrated.
Authors
- Tamal Ballav (ORCID: https://orcid.org/0009-0003-8980-2965)
- S. C. Barman (ORCID: https://orcid.org/0000-0002-2167-7454)
- Venkataraman Ganesh (ORCID: https://orcid.org/0000-0001-7893-109X)
Institutions
- Indian Institute of Technology Kharagpur (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1021/acs.orglett.5c00511
- Citations
- 3
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board