Replacing Mycophenolate Mofetil by Everolimus in Kidney Transplant Recipients to Increase Vaccine Immunogenicity: Results of a Randomized Controlled Trial
Six weeks' replacement of MMF by everolimus in KTRs does not improve COVID-19 booster vaccine immunogenicity, whereas 10 weeks' replacement enhances humoral HZ vaccine immunogenicity. While replacing MMF by everolimus may improve vaccine responses, its timing and potential risks require careful consideration.
Authors
- Ron T. Gansevoort (ORCID: https://orcid.org/0000-0002-3223-0906)
- Nelleke van Deursen
- Fréderike J. Bemelman (ORCID: https://orcid.org/0000-0002-4454-6270)
- Marcia M. L. Kho (ORCID: https://orcid.org/0000-0001-6313-5963)
- Carla C. Baan (ORCID: https://orcid.org/0000-0003-2274-2788)
- A. Lianne Messchendorp (ORCID: https://orcid.org/0000-0002-2792-142X)
- Luuk B. Hilbrands (ORCID: https://orcid.org/0000-0002-4935-9765)
- Debbie van Baarle (ORCID: https://orcid.org/0000-0001-5463-818X)
- Daryl Geers (ORCID: https://orcid.org/0000-0002-3432-0761)
- Susanne Bogers (ORCID: https://orcid.org/0000-0002-8212-2946)
- S. Reshwan K. Malahe (ORCID: https://orcid.org/0000-0003-1816-6589)
- Rory D. de Vries (ORCID: https://orcid.org/0000-0003-2817-0127)
- Sophie C. Frölke (ORCID: https://orcid.org/0000-0001-5296-6104)
- Marlies E. J. Reinders (ORCID: https://orcid.org/0000-0001-9543-567X)
- Corine H. GeurtsvanKessel (ORCID: https://orcid.org/0000-0002-7678-314X)
- Hanna Källmark (ORCID: https://orcid.org/0000-0003-3092-5074)
- Marc H. Hemmelder (ORCID: https://orcid.org/0000-0002-9598-1213)
- Alferso C Abrahams
- Meliha C Kapetanovic (ORCID: https://orcid.org/0000-0002-7853-514X)
- Dorien Standaar
- Marieken J. Boer-Verschragen
- Jan‐Stephan Sanders (ORCID: https://orcid.org/0000-0002-0904-3969)
- Marieke van der Heiden (ORCID: https://orcid.org/0000-0001-8525-9895)
- Helma Dolmans
- Janny G. Reinders
- Dennis A. J. van den Broek (ORCID: https://orcid.org/0000-0001-7135-4752)
- Katharina S. Schmitz (ORCID: https://orcid.org/0000-0002-8537-0646)
- Yvonne M.R. Adema
- Pim Bouwmans (ORCID: https://orcid.org/0000-0001-9977-8637)
- Johanna P. M. Vervoort (ORCID: https://orcid.org/0000-0002-0274-114X)
- Sietske van Berkel (ORCID: https://orcid.org/0000-0001-7275-0677)
- Aiko P. J. de Vries (ORCID: https://orcid.org/0000-0002-9284-3595)
- Céline Imhof (ORCID: https://orcid.org/0000-0003-4492-9009)
- Luca M. Zaeck (ORCID: https://orcid.org/0000-0001-7997-493X)
- Koen Wijnans
- Sandra Ahoud
- Arjan D. van Zuilen (ORCID: https://orcid.org/0000-0002-2561-5533)
- Matthew C. Becker (ORCID: https://orcid.org/0000-0002-8948-5723)
- Marc A G J ten Dam
- Monique Mullens
- Frederique Visscher
- Esther Eggenhuizen
- Xanne Huizenga
- Chantal van der Hurk
- Kimerley Hollander-Alblas
- Joëlle Noorlander
- Irma Stijman-Moerman
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Lund University (SE)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- Erasmus MC Transplant Institute
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1093/cid/ciaf107
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.96
Funders
- ZonMw
- Nierstichting