Ruthenium‐Catalyzed Site‐Selective Annulation of Benzoxazinones: An Easy Access to Dihydroisoquinoline Benzamide Derivatives
A ruthenium-catalyzed chelation-assisted substrate-controlled, site-selective, one-pot three-component cascade dehydrogenative annulation reaction is reported here. The developed methodology leads to the synthesis of biologically active 4H-benzo[d] [1,3] oxazin-4-one derivatives by the nucleophilic addition of amines to benzoxazinones followed by coupling with diphenyl acetylenes. In addition to providing excellent yields of products, the method is also regioselective. This new protocol has been demonstrated to have an easy access to a variety of dihydroisoquinoline benzamide derivatives.
Authors
- Brindaban C. Ranu (ORCID: https://orcid.org/0000-0001-9020-1401)
- Biju Majhi
- Laksmikanta Adak (ORCID: https://orcid.org/0000-0002-8544-7615)
- Subir Panja (ORCID: https://orcid.org/0000-0002-8682-6094)
- Chandan Nandi (ORCID: https://orcid.org/0000-0001-8670-7370)
- Keya Roy (ORCID: https://orcid.org/0000-0003-4984-1882)
- Biprajit Paul (ORCID: https://orcid.org/0000-0002-1944-8177)
- Anay Saha (ORCID: https://orcid.org/0009-0004-2423-1951)
Institutions
- Indian Association for the Cultivation of Science (IN)
- Indian Association for Cancer Research (IN)
- Institute of Engineering Science (RU)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
- Indian Institute of Engineering Science and Technology, Shibpur (IN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1002/chem.202500512
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian National Science Academy
- Department of Science and Technology, Ministry of Science and Technology, India