Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis
This study uses functional modeling and omics approaches to identify IGFBP5 as a candidate mediator of anti-tumor growth mechanisms originating from tumor-neighboring mesenchymal stromal cells. Tumors of mesenchymal origin, such as RMS, are known for their heterogeneity, and this could potentially pose a limitation to the study. However, a clinical relevance is emphasized by consistent findings across patient cohorts. These insights pave the way for novel therapeutic strategies modulating activities of stromal cell subsets at primary and metastatic sites in RMS.
Authors
- Monika Ehnman (ORCID: https://orcid.org/0000-0003-0468-2531)
- Liu Zhen Meng
- Nicholas P. Tobin
- Arne Östman
- Karim Katkhada
- Wiem Chaabane
- Shanlin Tong (ORCID: https://orcid.org/0000-0001-8502-4586)
- Aditi Kallai
- Alessandro Mega (ORCID: https://orcid.org/0000-0002-2230-5572)
- Yue Zhang (ORCID: https://orcid.org/0000-0003-2128-8472)
- Binbin Zhao (ORCID: https://orcid.org/0000-0001-7626-8087)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Bergen (NO)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12964-025-02171-6
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Mary Béves Stiftelse för Barncancerforskning
- Karolinska Institutet
- Barncancerfonden
- Cancerföreningen i Stockholm
- Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning