Thermodynamic parameters of the solubility of 3-(1,5-diphenylpyrrol-2-yl)propanoic acid in organic solvents

For the first time, the temperature dependence of the solubility of 3-(1,5-diphenylpyrrol-2-yl)propanoic acid was experimentally determined in eight organic solvents (methyl acetate, ethyl acetate, acetone, acetonitrile, n-propanol, isopropanol, n-butanol, and isobutanol) within the temperature range of 275.5–322.0 K at atmospheric pressure. Based on the solubility data, the enthalpies and entropies of solvation were calculated. Using differential thermal analysis, the enthalpy of fusion at the melting point (Tfus=442.41.5К) was determined. The equations for recalculating the enthalpies and entropies of fusion to 298 K are presented. The thermodynamic parameters of the mixing process of 3-(1,5-diphenylpyrrol-2-yl)propanoic acid with the solvents were also calculated. A compensation effect in the thermodynamic parameters of mixing was established, and the nature of the interactions between the solvent and the dissolved substance was analyzed.