Multiple doses of vaginal progesterone for singleton pregnant patients with previous preterm labour

Background and aim Preterm birth is still the major cause of handicaps among kids without congenital anomalies. This investigation aimed to ascertain the safety and effectiveness of various vaginal progesterone dosages to: Decrease the overall rate of spontaneous preterm births; Prolong pregnancy; and Enhance findings of newborns. Patients and methods This was a randomized prospective investigation performed on 105 pregnant females at the Obstetrics and Gynecology Department, Al-Azhar Assiut University Hospitals, and Isis Specialized Hospital at Luxor Governorate. Results A total of 16 patients in group A had Neonatal mortality in comparison to two cases had the same in group B in comparison to two patients had the same in group C, and this was highly statistically significant, while 14 patients in group A Fetal Respiratory distress syndrome, five patients in group B had the same, five patients in group C had the same, and this was statistically significant. Regarding Admission in NICU, 19, five, and four patients in groups A and B and group C, respectively, experienced this with high statistical significance. Regarding need for respiratory support, 20 cases in group A, 23 cases in group B, and 25 cases in group C there were no need for any support. While, two, three, and five patients in group A, B, and C needed nasal oxygen, respectively. Conclusion Vaginal progesterone may reduce preterm birth rates and prolong pregnancy latency, but optimal doses require further investigation. Higher doses may reduce adverse neonatal outcomes.