Fourteen anti-tick vaccine targets are variably conserved in cattle fever ticks
These findings emphasize the importance of thoroughly analyzing protein variation within anti-tick vaccine targets across diverse tick populations before selecting candidate vaccine antigens. When considering protein conservation alone, RmAQP1, vitellogenin receptor, serpin-1, subolesin, and especially VDAC rank as high-priority anti-tick vaccine candidates for use in the Americas and perhaps globally.
Authors
- Glen A. Scoles (ORCID: https://orcid.org/0000-0003-4161-0756)
- Greta Buckmeier
- Guilherme Klafke (ORCID: https://orcid.org/0000-0002-5620-2483)
- Massaro W. Ueti (ORCID: https://orcid.org/0000-0002-2680-6091)
- Joseph D. Busch (ORCID: https://orcid.org/0000-0003-4775-8225)
- Rebekah E. Turner
- Grant L. Pemberton
- Sara K. Davis
- Donald B. Thomas (ORCID: https://orcid.org/0000-0003-0373-2656)
- Shahid Karim (ORCID: https://orcid.org/0000-0001-8305-4394)
- Nathan E. Stone (ORCID: https://orcid.org/0000-0002-8723-359X)
- Juan Mosqueda (ORCID: https://orcid.org/0000-0001-8892-6390)
- Darrin Lemmer (ORCID: https://orcid.org/0000-0003-2785-6928)
- Jason W. Sahl (ORCID: https://orcid.org/0000-0002-2497-0138)
- Pia U. Olafson (ORCID: https://orcid.org/0000-0002-0433-6172)
- David M. Wagner (ORCID: https://orcid.org/0000-0003-2684-6007)
- Roberto I. Guerrero-Solorio
- Mackenzie L. Roberts
- Natalie B. Thornton
Institutions
- Agricultural Research Service (US)
- Autonomous University of Queretaro (MX)
- Northern Arizona University (US)
- Flagstaff Medical Center (US)
- Fundação Estadual de Pesquisa Agropecuária (BR)
- Beltsville Agricultural Research Center (US)
- Knipling-Bushland U.S. Livestock Insects Research Laboratory (US)
- University of Southern Mississippi (US)
- Washington State University (US)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s13071-025-06683-5
- Citations
- 3
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.14
Funders
- U.S. Department of State
- U.S. Department of Agriculture
- Texas Animal Health Commission
- Northern Arizona University
- National Institute of Food and Agriculture
- Agricultural Research Service
- Animal and Plant Health Inspection Service