[The analysis of short-term prognosis and influencing factors in patients with upper gastrointestinal bleeding combined with stable coronary artery disease].

<b>Objective:</b> To analyze the short-term prognosis and influencing factors of patients with upper gastrointestinal bleeding combined with stable coronary artery disease (CAD). <b>Methods:</b> Retrospective analysis was performed on patients with upper gastrointestinal bleeding admitted to Beijing Anzhen Hospital Affiliated to Capital Medical University for emergency gastroscopy treatment from January 2022 to December 2023. All patients were followed up until 30 days after discharge, and the deadline for follow-up was February 2024. They were divided into the combined group (patients with stable CAD) and the non-combined group according to whether they were complicated with CAD.The difference in clinical characteristics and prognosis of the both groups were compared. Based on whether adverse events occurred, the CAD group was further divided into the poor prognosis group (patients with rebleeding or new cardiovascular and cerebrovascular ischemic events) and the good prognosis group. The differences of the clinical data between the two subgroups were compared. Furthermore, receiver operating characteristic (ROC) curve was used to determine cut-off value. Multivariate logistic regression model was used to analyze the influencing factors of poor prognosis in patients with upper gastrointestinal bleeding combined with stable CAD. <b>Results:</b> A total of 273 patients were included, including 95 cases in the combinde group [71 males and 24 female, aged (63.4±9.7) years ] and 178 cases in non-combined group [119 males and 59 females, aged (61.5±15.9) years]. Each patient was followed up for 30 days. The patients in the CAD group had higher Glasgow-Blatchford scores [<i>M</i> (<i>Q</i>₁<i>, Q</i>₃) was 12 (10, 15) vs 8 (7, 11) score] and Rockall scores[6 (5, 7) vs 4 (2, 4) score] than those in the non-combined group; The combined group had a higher incidence of rebleeding [7.4% (7/95) vs 1.1% (2/178)], the incident of new ischemic events [8.4% (8/95) vs 0], the incidence of acute myocardial infarction [6.3% (6/95) vs 0] and morality [3.2% (3/95) vs 0] were higher than those of the non-CAD group (all <i>P</i><0.05). There were 15 cases in the poor prognosis group, including 10 males and 5 females, aged (65.1±8.4) years. And there were 80 cases in the good prognosis group, including 56 males and 24 females, aged (63.1±10.0) years. The lowest hemoglobin level in the poor prognosis group was lower than that in the good prognosis group [ 65 (59, 73) vs 76 (66, 86) g/L]; The Glasgow-Blatchford score in the poor prognosis group was higher than that in the good prognosis group [16 (15, 17) vs 11 (10, 14) score] (all <i>P</i><0.05). The area under the ROC curve of the Glasgow-Blatchford score was 0.868 (95%<i>CI</i>: 0.791-0.945), the cut-off value was 13.5 score, and the sensitivity and specificity were 93.3% and 30.0%, respectively. Glasgow-Blatchford score>13.5 score was a risk factor for adverse events in patients with upper gastrointestinal hemorrhage combined with stable CAD (<i>OR</i>=21.372, 95%<i>CI</i>: 2.482-184.007). <b>Conclusions:</b> The incidence of short-term adverse events in patients with upper gastrointestinal bleeding combined with stable CAD is higher than that in non-combined group. The Glasgow-Blatchford score>13.5 score is a risk factor for short-term adverse events in patients with upper gastrointestinal bleeding combined with CAD.