Identification and Verification of Key Genes Associated with Temozolomide Resistance in Glioblastoma Based on Comprehensive Bioinformatics Analysis.
PITX1, TNFRSF11B, and IGFBP2 are key genes associated with the prognosis of GBM patients with TMZ resistance. The differential expression of these genes correlates with adverse outcomes in GBM patients, suggesting that they are valuable biomarkers for predicting patient prognosis and that they could serve as diagnostic biomarkers or treatment targets.
Authors
- Zongting Shi
- Weiheng Chen
- Tiemin Hu
- Baohong Mi (ORCID: https://orcid.org/0000-0002-6305-2110)
- Jingyan Yang (ORCID: https://orcid.org/0000-0001-5523-649X)
- Hong Wang (ORCID: https://orcid.org/0000-0001-6905-438X)
- Na Hu (ORCID: https://orcid.org/0000-0003-4109-4122)
- Jun Hu (ORCID: https://orcid.org/0000-0001-8866-9718)
Institutions
- Beijing University of Chinese Medicine (CN)
- Affiliated Hospital of Hebei University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.30498/ijb.2024.448826.3892
- Citations
- 1
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.42