Combination Therapy of Oncolytic Newcastle Virus and Lenalidomide Enhanced Cytotoxicity in Prostate Cancer Cells
Our study confirms the efficacy of oncolytic NDV treatment for PCa, particularly utilizing the La Sota strain. When combined with Len, NDV indicates an enhanced effectiveness in destroying tumor cells. These findings suggest a prospective treatment approach that needs more preclinical and clinical studies to improve outcomes in PCa treatment.
Authors
- Mahdie Jafari
- Masoud Moghaddam Pour (ORCID: https://orcid.org/0000-0002-5307-7226)
- Zahra Sharifzadeh (ORCID: https://orcid.org/0000-0002-4419-0315)
- Mohammad Ali Shokrgozar (ORCID: https://orcid.org/0000-0001-5123-4155)
- Shahriyar Abdoli (ORCID: https://orcid.org/0000-0002-4052-332X)
- Majid Asgari (ORCID: https://orcid.org/0000-0003-1167-2550)
Institutions
- Pasteur Institute of Iran (IR)
- Razi Vaccine and Serum Research Institute (IR)
- Golestan University (IR)
- Biotechnology Research Center (IR)
- Golestan University of Medical Sciences (IR)
- Winthrop Rockefeller Foundation (US)
Publication Details
- Journal
- Iranian Biomedical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.61882/ibj.4367
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pasteur Institute of Iran