Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism
The link between lipids and MDD features cannot be adequately estimated by combining participants with and without MetS. It should be examined in a study sample that excludes subjects with MetS. The depression phenome, suicidal behaviors, and neuroticism correlate with diminished RCT and heightened atherogenicity, which are likely implicated in the pathophysiology of MDD. Increased atherogenicity and lowered RCT may represent novel drug targets for the treatment and prevention of MDD, neuroticism, and suicidal behaviors.
Authors
- Abbas Firras Almulla (ORCID: https://orcid.org/0000-0002-7667-6731)
- Marta Kubera (ORCID: https://orcid.org/0000-0003-4401-5055)
- Chavit Tunvirachaisakul (ORCID: https://orcid.org/0000-0001-9356-1461)
- Ketsupar Jirakran (ORCID: https://orcid.org/0000-0002-5690-8216)
- Asara Vasupanrajit
- Michael Maes
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Iraqi University (IQ)
- Maj Institute of Pharmacology (PL)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12888-025-06734-2
- Citations
- 14
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 19.45
Funders
- King Chulalongkorn Memorial Hospital
- Chulalongkorn University
- Thailand Science Research and Innovation
- Faculty of Medicine, Chulalongkorn University