Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma
Necrosis cores which are surrounded by hypoxic and perivascular niches and microvascular proliferation area within the glioblastoma tumor microenvironment, have been considered as standardized morphological indicators of aggressive GBM. Our findings provide a cellular and molecular insights into GBM progression.
Authors
- Jie Wu (ORCID: https://orcid.org/0000-0001-6963-0244)
- Sami Siraj (ORCID: https://orcid.org/0000-0002-4595-0232)
- Nafees Ahmad (ORCID: https://orcid.org/0000-0002-7436-7644)
- Shaheryar Shafi (ORCID: https://orcid.org/0000-0002-1936-4838)
- Xiaohan Sa
- Yuanshuai Zhou (ORCID: https://orcid.org/0000-0003-0007-4723)
- Minxuan Sun (ORCID: https://orcid.org/0000-0003-2033-6268)
- James C. Hu (ORCID: https://orcid.org/0000-0001-9016-2684)
- Jiao Yang (ORCID: https://orcid.org/0000-0002-1553-5425)
- Yue Yang (ORCID: https://orcid.org/0009-0000-8974-8151)
- Yuwen Han
Institutions
- Shanghai University (CN)
- University of Science and Technology of China (CN)
- Khyber Medical University (PK)
- Suzhou Institute of Biomedical Engineering and Technology (CN)
- Suzhou Municipal Hospital (CN)
- Institute of Biomedical and Genetic Engineering (PK)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12967-025-06185-z
- Citations
- 11
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.88
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Government of Jiangsu Province