Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension
IPAH monocytes exhibit an altered activation state associated with reduced BMPR2 and CD14, along with elevated STAT1-IFN expression. These changes are linked to intrinsic functional abnormalities that contribute to the monocytes' increased propensity to invade the pulmonary circulation.
Authors
- François Haddad (ORCID: https://orcid.org/0000-0002-9648-7671)
- Rebecca L. Harper (ORCID: https://orcid.org/0000-0003-1465-7372)
- David P. Marciano (ORCID: https://orcid.org/0000-0001-8868-2138)
- Aiqin Cao
- Shoichiro Otsuki (ORCID: https://orcid.org/0000-0002-8379-8673)
- Michael Snyder (ORCID: https://orcid.org/0000-0003-0784-7987)
- Manfred Boehm (ORCID: https://orcid.org/0000-0002-2251-3638)
- Marcy Martin (ORCID: https://orcid.org/0000-0003-0035-0185)
- Wenyu Zhou (ORCID: https://orcid.org/0000-0002-8447-8815)
- Marlene Rabinovitch (ORCID: https://orcid.org/0000-0001-7886-7104)
- Roham T. Zamanian (ORCID: https://orcid.org/0000-0002-0734-0994)
- Jordan Burgess
- Sarasa Isobe (ORCID: https://orcid.org/0000-0002-7405-0903)
- Mir S Adil
- Vignesh Viswanathan (ORCID: https://orcid.org/0000-0001-8307-9508)
- Xin Zhou (ORCID: https://orcid.org/0000-0003-4015-4787)
- Andrew Hsi
- Peter Maguire (ORCID: https://orcid.org/0000-0002-1051-3921)
- Patricia A. del Rosario
- Lingli Wang (ORCID: https://orcid.org/0000-0003-2756-5346)
- Guibin Chen (ORCID: https://orcid.org/0000-0001-5520-1780)
- Devon Kelley
- Quan Yu
- A. Inglis
- Dan Yang (ORCID: https://orcid.org/0000-0001-9984-7225)
- Shanthi Deivanayagam
Institutions
- Cardiovascular Institute of the South (US)
- National Heart, Lung, and Blood Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12931-025-03182-0
- Citations
- 3
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- American Heart Association
- Vanderbilt University
- Cardiovascular Medical Research and Education Fund
- Pakistan Atomic Energy Commission
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute