Weight Loss Reverses the Effects of Aging and Obesity on Mammary Tumor Immunosuppression and Progression
Advanced age and obesity are important risk factors for the development and progression of breast cancers, including TNBC. We demonstrate that the suppression of signatures of antitumor immunity is a common feature of accelerated tumor progression in TNBC. We show that weight loss achieved through calorie restriction can restore such markers. See related Spotlight, p. 437.
Authors
- Elaine M. Glenny (ORCID: https://orcid.org/0000-0002-1024-4290)
- Meredith S. Carson (ORCID: https://orcid.org/0000-0002-2186-0195)
- Alyssa N. Ho (ORCID: https://orcid.org/0009-0003-1797-6907)
- Dalton M. Craven (ORCID: https://orcid.org/0009-0004-1373-0173)
- Stephen David Hursting (ORCID: https://orcid.org/0000-0003-3605-2833)
- Michael F. Coleman (ORCID: https://orcid.org/0000-0002-6914-848X)
- Erika T. Rezeli (ORCID: https://orcid.org/0000-0001-5468-0150)
- Alyssa J. Cozzo (ORCID: https://orcid.org/0000-0001-6690-4748)
- Evan M. Paules (ORCID: https://orcid.org/0000-0002-8344-818X)
- Magdalena Fay (ORCID: https://orcid.org/0000-0002-6086-931X)
- Laura A. Smith
Institutions
- University of North Carolina at Chapel Hill (US)
- David H. Murdock Research Institute (US)
- University of North Carolina System (US)
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1158/1940-6207.capr-24-0514
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81