Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway
Our study indicates that HLJD alleviates cognitive deficits in AD by suppressing the Trem2/Dap12 signaling pathway in the HIP of 5xFAD mice, thereby inhibiting microglial neuroinflammation.
Authors
- Vincent W. Keng (ORCID: https://orcid.org/0000-0003-3473-0653)
- Ran Pang (ORCID: https://orcid.org/0000-0002-5101-8249)
- Kai Le (ORCID: https://orcid.org/0000-0002-7625-2920)
- Shijie Zhang (ORCID: https://orcid.org/0000-0002-8041-0581)
- Shan Su (ORCID: https://orcid.org/0000-0002-3324-0540)
- Xiaoyu Peng (ORCID: https://orcid.org/0000-0002-4376-1331)
- Jiayi Zheng (ORCID: https://orcid.org/0000-0001-9756-386X)
- Jia Shi (ORCID: https://orcid.org/0000-0002-6912-6803)
- Xiao-Xiao Li (ORCID: https://orcid.org/0000-0002-3529-6222)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Beijing Normal-Hong Kong Baptist University (CN)
- Nanchang University (CN)
- Hong Kong Polytechnic University (HK)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Zhuhai Institute of Advanced Technology (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s13020-025-01098-x
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84