A Clinical Validation Of Efficacy And Safety Of Polyherbal Formulation For Symptomatic Relief Of Acute Non-Productive Cough And Throat Irritation.

Introduction: Acute nonproductive cough, often caused by upper respiratory tract infections, is a very common and disturbing symptom. Conventional treatments often cause undesirable side effects, and existing herbal formulations lack sufficient efficacy data, highlighting the need for safer approaches. A randomized, controlled clinical study that compared efficacy of polyherbal syrup (GP/PROD/2021/004) versus marketed syrup for relief of acute nonproductive cough and throat irritation. Method: A randomized, parallel-group, multicentric, active-controlled clinical trial enrolled 65 participants aged 18-65 years with acute nonproductive cough. Participants were randomized to receive either the polyherbal syrup (test group) or marketed syrup (control group) for five days. Outcomes included changes in day/night cough frequency, throat irritation, symptom relief duration, and drowsiness using various Likert scales. Results: After five days of treatment with the polyherbal syrup (GP/PROD/2021/004), 83.3% of participants experienced relief from daytime cough, while 90% reported relief from nighttime cough. More than 90% of participants showed improvement in throat irritation, chest pain, wheezing, and shortness of breath. Notably, all participants reported complete resolution of throat clearing and sore throat, and 95% experienced relief from cough and throat irritation after their first morning dose. No adverse events were reported, and no recurrence of cough symptoms was observed following treatment discontinuation. Conclusion: The polyherbal syrup demonstrated significant efficacy in alleviating acute nonproductive cough and associated symptoms, providing rapid and sustained relief without inducing drowsiness or symptom recurrence. These findings support the potential role of polyherbal syrup in offering effective, well-tolerated alternatives for cough management. Keywords : Endocannabinoid system; Immune system; Ramos cell line; Daudi cell line; Raji cell line; Jurkat cell line; Molt-4 cell line.