Facile post-synthesis of isomeric covalent organic frameworks <i>via</i> precise pore surface engineering

Isomeric covalent organic frameworks (COFs) have developed dramatically due to having the same chemical composition but distinct physicochemical characteristics. However, exploring novel synthetic strategies for the precise construction of COFs with isomeric pore microenvironments remains challenging and in its infancy. In this contribution, we have developed a controllable, simple, and efficient post-synthesis modification strategy to design isomeric COFs <i>via</i> precise pore surface engineering. The as-prepared isomeric COFs showed comparable crystallinity and porosity but significantly different pore microenvironments. Interestingly, the isomeric moieties endow the isomeric COFs with specific capture performances and excellent recycling ability. The specific interactions between these isomeric COFs and guests are verified by fluorescence spectra and theoretical calculation. This study will open a novel avenue for the construction of isomeric COFs and facilitate the development of isomeric COFs with specific properties.