Acute side effects of proton and photon radiotherapy for medulloblastoma: a retrospective national multicenter study
This is one of the largest studies comparing acute side effects of proton-RT and photon-RT including only paediatric medulloblastoma patients. Proton-RT was safe and well tolerated regarding acute side effects. Absorbed dose to intracranial OARs was significantly lower with proton-RT. Further investigations of long-term side effects and cognitive evaluation is needed to show that this will translate into true clinical value for patients.
Authors
- Måns Agrup
- Anna Embring (ORCID: https://orcid.org/0000-0002-5147-3276)
- Jacob Engellau (ORCID: https://orcid.org/0000-0003-4424-5985)
- Angelica Walfridsson
- Malin Blomstrand
- Charlotta A. Frojd (ORCID: https://orcid.org/0009-0005-5415-6945)
- Anna-Maja Svärd
- Anna Flejmer (ORCID: https://orcid.org/0000-0001-8425-8110)
- Linn Söderlund Diaz (ORCID: https://orcid.org/0000-0002-2250-9831)
- Martin Nilsson (ORCID: https://orcid.org/0000-0002-7419-6750)
- Ingrid Kristensen (ORCID: https://orcid.org/0000-0002-2742-0887)
- Anna Askild
Institutions
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Skåne University Hospital (SE)
- Linköping University Hospital (SE)
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1007/s11060-025-05016-x
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Varian Medical Systems
- Göteborgs Universitet