Horner Syndrome : Gateway to Neuro-Behçet Syndrome

Background: Horner syndrome (HS), a rare neurological condition caused by disruption of the oculosympathetic pathway, can occasionally serve as an early indicator of systemic diseases such as Behçet syndrome (BS). Neuro-Behçet syndrome (NBS) represents a severe manifestation of BS affecting the central nervous system (CNS). It is associated with significant morbidity. Case Description: This report describes an unusual case of NBS revealed by HS in 43-year-old male who initially presented with progressive-onset left ptosis. The symptomatology was enriched by left-sided hemicranial headaches and homolateral carotidynia. NBS diagnosis was established after ruling out other potential differential diagnosis. The association of corticosteroids (CSs) and other immunosuppressants (ISs) led to a significant improvement. Conclusion: Considering atypical revelation’s mode of NBS remains a noteworthy occurrence for clinicians. Prompt diagnosis and intervention are crucial to prevent further neurological deterioration.