Strain-Dependent Susceptibility to Prion Infection Encoded by Arg171 and Lys176 Sheep Prion Protein Polymorphic Variants
These results indicate that the R171 and K176 polymorphic variants of the ovine PrP sequence restrict the propagation of prions in a strain-dependent manner and are useful tools for prion strain discrimination.
Authors
- Romolo Nonno (ORCID: https://orcid.org/0000-0001-7556-1564)
- Patricia Aguilar‐Calvo
- Sylvie L. Benestad (ORCID: https://orcid.org/0000-0002-3011-0484)
- Juan María Torres (ORCID: https://orcid.org/0000-0003-0443-9232)
- Natalia Fernández‐Borges (ORCID: https://orcid.org/0000-0001-6274-0096)
- Olivier Andréoletti (ORCID: https://orcid.org/0000-0002-7369-6016)
- Belén Pintado (ORCID: https://orcid.org/0000-0002-8485-2520)
- Juan Carlos Espinosa (ORCID: https://orcid.org/0000-0002-6719-9902)
- Alba Marín‐Moreno (ORCID: https://orcid.org/0000-0002-4023-6398)
- Sara Canoyra (ORCID: https://orcid.org/0000-0001-6371-8122)
- Eva Pericuesta (ORCID: https://orcid.org/0000-0001-9387-3270)
Institutions
- Transgene (France) (FR)
- École Nationale Vétérinaire de Toulouse (FR)
- Institut National Polytechnique de Toulouse (FR)
- Istituto Superiore di Sanità (IT)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centro Nacional de Biotecnología (ES)
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (ES)
- Norwegian Institute of Bioeconomy Research (NO)
- Centro de Biología Molecular Severo Ochoa (ES)
- Interactions hôtes-agents pathogènes (FR)
- Norwegian Veterinary Institute (NO)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1093/infdis/jiaf170
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Animal and Plant Health Agency