Development and Evaluation of Candesartan-Loaded Proliposomes for Improved Bioavailability

This study focused on developing candesartan-loaded proliposomes to enhance the solubility and permeability of candesartan drug. Proliposomes were prepared using the thin film hydration technique. Formulations were developed by varying the ratio of the lipid HSPC and cholesterol, while same consistent quantity of carrier. These formulations were then evaluated to determine the optimal size, entrapment efficiency, and enhanced in vitro dissolution. Dynamic light scattering analysis showed the particles had a size range of 450.3±2.2 to 480.4±2.31 nm and a zeta potential between -39 and -38 mV. Fourier transform infrared spectroscopic analysis showed that the drug was compatible with the excipients, with no interactions detected. Powder X-ray diffraction analysis indicated that the pure drug was crystalline, but was transformed into an amorphous form within the formulation. The in vitro drug release study using a dialysis membrane displayed enhanced dissolution of the drug due to the hydrophilic carrier, followed by sustained drug release owing to the lipid mixture of HSPC and cholesterol.