Time to Occurrence of Incontinence-Associated Dermatitis: An Experimental Animal Study
The IAD model established using synthetic fecal exposure effectively facilitates mechanistic research. Skin tissue became loose and edematous, with a significant increase in inflammatory factors within 0.5h. These findings suggest that fecal contamination should be removed within 0.5h to prevent skin damage. Additionally, IL-1α, IL-6, and TNF-α are promising biomarkers for IAD-associated skin injury.
Authors
- Xiaoru Wang
- Junfang Duan (ORCID: https://orcid.org/0000-0002-4858-6405)
- Chenli Xu
- Xiaojuan Liang (ORCID: https://orcid.org/0000-0003-1671-967X)
- Junli Wang (ORCID: https://orcid.org/0000-0001-6862-1944)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7657-0718)
- Jian Peng (ORCID: https://orcid.org/0000-0002-9763-4741)
- Dajiang Yuan
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Anhui Provincial Children's Hospital (CN)
- Shanxi Cardiovascular Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jir.s511464
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanxi Medical University