Alpha‐Glucosidase and Nitric Oxide Inhibitors From <i>Paramignya trimera</i> Leaves and <i>Dicranopteris linearis</i> Spores: In Silico and In Vitro Aspects
Dicranopteris linearis and Paramignya trimera, widely utilized plants in traditional Vietnamese medicine, lack comprehensive chemical and biological data pertaining to their composition. The crude extracts of these biosources showed remarkable alpha-glucosidase and nitric oxide (NO) inhibition. Bioguided isolation based on alpha-glucosidase inhibition and anti-inflammatory activity was applied to P. trimera and D. linearis, providing 14 metabolites. Upon evaluating the alpha-glucosidase activity of compounds 1-14, it was observed that all tested compounds exhibited significant activity, with IC<sub>50</sub> values ranging from 22.5 to 157.7 µM. Notably, compound 14 was identified as a new compound. Compounds 6-8 exhibited potent NO inhibitory effect in LPS-induced RAW264.7 macrophage cells, with IC<sub>50</sub> values ranging from 26.65 to 28.79 µg/mL.
Authors
- Ngoc‐Hong Nguyen (ORCID: https://orcid.org/0009-0003-1281-5346)
- Thi-Phuong Nguyen (ORCID: https://orcid.org/0000-0002-6406-1406)
- Thuc‐Huy Duong (ORCID: https://orcid.org/0000-0001-9891-4326)
- Tuan-Dat Nguyen
- Huong Thuy Le (ORCID: https://orcid.org/0009-0000-8398-3257)
- Xuan‐Hao Bui (ORCID: https://orcid.org/0009-0006-7962-6998)
- Thi‐Hoai‐Thu Nguyen
- Thi Nhung Ngo (ORCID: https://orcid.org/0009-0000-3263-8576)
- Sichaem Jirapast
Institutions
- Thammasat University (TH)
- Ton Duc Thang University (VN)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Trường ĐH Nguyễn Tất Thành (VN)
- Lampang Rajabhat University (TH)
- Ho Chi Minh City University of Education (VN)
- Ho Chi Minh City University of Technology (VN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1002/cbdv.202500588
- Citations
- 1
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.81