Endocrine Maintenance Therapy in High-Grade Serous Ovarian Cancer: A Retrospective Off-Label Real-World Cohort Study
Maintenance letrozole therapy appears to be a well-tolerated and potentially beneficial intervention in a subset of patients with ER-positive HGSC with no residual disease post-treatment. These findings highlight the need for further validation through prospective randomized trials to comprehensively assess the efficacy of endocrine therapy in this setting and its implications for patient quality of life.
Authors
- Bich Doan Nguyen-Sträuli (ORCID: https://orcid.org/0000-0003-1290-830X)
- Viola A Heinzelmann-Schwarz (ORCID: https://orcid.org/0000-0002-5613-8629)
- Andreas Schötzau
- Fabrice E. Graf (ORCID: https://orcid.org/0000-0003-1132-5348)
- Ursula Gobrecht-Keller
- Tibor A. Zwimpfer (ORCID: https://orcid.org/0000-0002-1574-6572)
- Ruth S. Eller (ORCID: https://orcid.org/0000-0003-0573-4452)
- Franziska Geissler (ORCID: https://orcid.org/0000-0003-3568-2008)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-12
- DOI
- https://doi.org/10.3390/cancers17081301
- Citations
- 1
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Krebsliga Schweiz
- Gottfried und Julia Bangerter-Rhyner-Stiftung
- Swiss Cancer Research Foundation