Elucidation of the mechanism Underlying the promotion of ferroptosis and enhanced antitumor immunity by citrus polymethoxyflavones in CRC cells
It is conceivable that the tumor immune microenvironment may be subject to regulation during the inhibition of colon cancer through ferroptosis in PMFs. The ferroptosis-related gene <i>TIMP1</i> has been observed to regulate <i>PD-L1</i>, thereby promoting anti-tumor immunity in colon cancer. However, further investigation is required to ascertain the underlyingprecise mechanisms.
Authors
- Zhongwen Yuan (ORCID: https://orcid.org/0000-0002-5082-7909)
- Yu Wu (ORCID: https://orcid.org/0000-0002-3435-1074)
- Li Chen (ORCID: https://orcid.org/0000-0001-5561-7612)
- Yuqin Yin (ORCID: https://orcid.org/0000-0002-0980-6954)
- Senling Feng (ORCID: https://orcid.org/0000-0001-8326-2046)
- Wenting Zhu (ORCID: https://orcid.org/0000-0001-8910-0523)
- Jiaqi Tian (ORCID: https://orcid.org/0009-0007-6574-6945)
- Yingying Duan (ORCID: https://orcid.org/0000-0002-0979-4308)
- S. Zhou
Institutions
- Guangxi Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fphar.2025.1571178
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province