Effects of Pigs’ Weaning Weight on Growth Performance and Blood Immunological, Antioxidant, and Gut Permeability Parameters in Early Nursery Period

This study was conducted to investigate the effect of pigs' weaning weight (WW) on their growth performance and blood immunological, antioxidant, and gut permeability parameters in the early nursery period. At weaning, a total of 48 pigs, weaned at 20.7 ± 0.74 d of age, were allotted to two WW categories-HWW, with a WW over 5.5 kg (average 6.79 ± 0.53 kg), and LWW, with a WW of less than 5.5 kg (average 4.43 ± 0.56 kg)-for a 14 d postweaning period. The WW did not affect the average daily gain (ADG) in d 0-7 postweaning or the plasma malondialdehyde levels over the entire period. HWW pigs had a higher body weight and ADG than LWW pigs (<i>p</i> < 0.05) in the overall period, with greater plasma immunoglobulin G (<i>p</i> < 0.05) and A (<i>p</i> = 0.06, tendency) levels at d 7 postweaning and superoxide dismutase activity at d 14 postweaning (<i>p</i> = 0.05, tendency), with positive correlations with the WW (<i>p</i> < 0.05). HWW pigs had lower plasma diamine oxidase (<i>p</i> < 0.05) and d-lactate (<i>p</i> = 0.06, tendency) levels at d 14 postweaning, with a negative correlation with the WW (<i>p</i> < 0.05). In conclusion, although there was no effect of the WW on growth rate in the first week postweaning and oxidative stress in the early nursery period, HWW pigs exhibited greater growth performance, immunoglobulin levels, and antioxidant capacity but lower gut permeability than LWW pigs in the early nursery period.