Downregulation of EB1 impedes Cx43 localization and cardiac conduction after hypothermic ischemia-reperfusion in rats
EB1 downregulation following hypothermic ischemia-reperfusion was accompanied by a reduction in gap junction Cx43. EB1 overexpression improved cardiac conduction and reduced reperfusion arrhythmias by promoting Cx43 localization to IDs, facilitating gap junctions (GJs) formation. These findings contribute to the development of new therapeutic targets for reperfusion arrhythmias.
Authors
- An Li (ORCID: https://orcid.org/0000-0001-5750-526X)
- Chunlei Wen
- Rongfeng Yang
- Ying Cao (ORCID: https://orcid.org/0000-0003-0699-1039)
- Zijun Wang (ORCID: https://orcid.org/0000-0002-2095-2151)
- Yuting Song (ORCID: https://orcid.org/0000-0002-9481-4392)
- Hong Gao (ORCID: https://orcid.org/0009-0006-9622-1837)
- Jing Yi (ORCID: https://orcid.org/0000-0002-8334-1825)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- The First People's Hospital of Guiyang (CN)
- Xian Yang Central Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-04-14
- DOI
- https://doi.org/10.7717/peerj.19276
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.81