Enhanced disgust generalization in obsessive–compulsive disorder is related to insula and putamen hyperactivity
Hyperactivation of the insula and putamen during disgust generalization neutrally mediates the higher degree of disgust generalization in subclinical OCD individuals. This study indicates that altered disgust generalization plays an important role in individuals with high contamination concerns and provides evidence of the neural mechanisms involved. These insights may serve as a basis for further exploration of the pathogenesis of OCD in the future.
Authors
- Xianchao Ming
- Benjamin Becker (ORCID: https://orcid.org/0000-0002-9014-9671)
- Yuchen Song (ORCID: https://orcid.org/0000-0001-5684-7321)
- Juntong Liu (ORCID: https://orcid.org/0009-0001-6748-2898)
- Yi Lei (ORCID: https://orcid.org/0000-0002-8874-923X)
- Jinxia Wang (ORCID: https://orcid.org/0000-0003-1946-7922)
Institutions
- Shenzhen University (CN)
- South China Normal University (CN)
- Shenzhen Institute of Neuroscience (CN)
- Sichuan Normal University (CN)
- University of Hong Kong (HK)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725000728
- Citations
- 3
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.92
Funders
- Ministry of Education Key Projects of Philosophy and Social Sciences Research